Role of pyloric antrum in choleresis after insulin and feeding

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Abstract
Mongrel dogs were prepared with chronic gastric and duodenal cannulas after removal of the gallbladder and section of the lesser pancreatic duct. Bile was collected in 4 1 -hr. periods following trans -duodenal catheterization of the common bile duct. After the 1st hr. of collection the dogs were stimulated by feeding of insulin 1.5 U/kg intravenously, and the secretory responses were compared with controls. The pyloric antrum was then removed, and after recovery, the feeding and insulin experiments were repeated. Before antrec-tomy, insulin and feeding resulted in a significant increase in the bile flow and output of total solids. Following antrectomy the insulin choleresis was almost abolished, but the feeding response was unchanged. The pyloric antrum is necessary for the usual choleretic response to insulin hypoglycemia and probably the source of a choleretic agent released by vagal stimulation. The antrum is unnecessary for the choleresis after feeding.

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