A controlled trial of photochemotherapy for persistent palmoplantar pustulosis

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Abstract
Patients (22) with bilaterally symmetrical persistent palmoplantar pustulosis were treated on randomly selected side with oral psoralen and long-wave UV. The treated side cleared completely in 12 patients, almost cleared in 5 patients and improved in 4. A patient improved on both sides. Of the 22 patients 15 were than treated with topical psoralen and long-wave UV on the side that had previously been used as a control. Similar results were obtained. Some 7 patients cleared completely, 6 patients were much improved and 2 were improved. These results are significantly different from those liable to occur by chance (P < 0.001).