Crystal Structure Analysis of Deamino-Oxytocin: Conformational Flexibility and Receptor Binding
- 2 May 1986
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 232 (4750) , 633-636
- https://doi.org/10.1126/science.3008332
Abstract
Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.This publication has 17 references indexed in Scilit:
- Dynamics and Conformational Energetics of a Peptide Hormone: VasopressinScience, 1985
- Pharmacological, conformational and dynamic properties of cycloleucine‐2 analogues of oxytocin and [1‐penicillamine]oxytocinInternational Journal of Peptide and Protein Research, 1983
- Unusual intramolecular hydrogen bonding in cycloamanide A, cyclic (LPro‐LVal‐LPhe‐LPhe‐LAla‐Gly)International Journal of Peptide and Protein Research, 1982
- Conformational studies on [3-D-alanine]-oxytocin and [4-D-alanine]-oxytocin in dimethyl sulfoxide by proton nuclear magnetic resonance spectroscopy. Interpretation in terms of a .beta. turn in the cyclic moietyJournal of the American Chemical Society, 1977
- A Raman spectroscopic investigation of the disulfide conformation in oxytocin and lysine vasopressinBiochemistry, 1977
- Solid state conformation of the C-terminal tripeptide of oxytocin, L-Pro-L-Leu-Gly-NH2.0.5H2OJournal of the American Chemical Society, 1973
- Secondary Structure of the Cyclic Moiety of the Peptide Hormone Oxytocin and Its Deamino AnalogProceedings of the National Academy of Sciences, 1970
- Oxytocin: Crystal Date of a Seleno AnalogScience, 1969
- Deamino Oxytocin and 1-γ-Mercaptobutyric Acid-Oxytocin: X-ray Crystallographic DataScience, 1966
- THE SYNTHESIS OF AN OCTAPEPTIDE AMIDE WITH THE HORMONAL ACTIVITY OF OXYTOCINJournal of the American Chemical Society, 1953