The Genomes of Recombinant Inbred Lines
- 1 February 2005
- journal article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 169 (2) , 1133-1146
- https://doi.org/10.1534/genetics.104.035212
Abstract
Recombinant inbred lines (RILs) can serve as powerful tools for genetic mapping. Recently, members of the Complex Trait Consortium proposed the development of a large panel of eight-way RILs in the mouse, derived from eight genetically diverse parental strains. Such a panel would be a valuable community resource. The use of such eight-way RILs will require a detailed understanding of the relationship between alleles at linked loci on an RI chromosome. We extend the work of Haldane and Waddington on two-way RILs and describe the map expansion, clustering of breakpoints, and other features of the genomes of multiple-strain RILs as a function of the level of crossover interference in meiosis.Keywords
This publication has 18 references indexed in Scilit:
- The Collaborative Cross, a community resource for the genetic analysis of complex traitsNature Genetics, 2004
- Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effortMammalian Genome, 2002
- Markov ChainsPublished by Cambridge University Press (CUP) ,1997
- A general algorithm to compute multilocus genotype frequencies under various mating systemsBioinformatics, 1996
- R: A Language for Data Analysis and GraphicsJournal of Computational and Graphical Statistics, 1996
- R: A Language for Data Analysis and GraphicsJournal of Computational and Graphical Statistics, 1996
- On genetic map functions.1996
- On Genetic Map FunctionsGenetics, 1996
- Inbreeding and linkage1931
- INBREEDING AND LINKAGEGenetics, 1931