Some pharmacokinetic characteristics of furafylline, a new 1,3,8-trisubstituted xanthine

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Abstract
After administration of furafylline, a, 1,3,8‐trisubstituted xanthine, to beagle dogs at 0.5 and 10 mg kg−1 an elimination half‐life 2–10 times longer than that of theophylline was observed. The kinetics were dose‐dependent but no phase I metabolites were detected. When the compound was given orally to humans at a dose of 1.3–1.9 mg kg−1 a mean β elimination half‐life of 48.1 ± 10.8 h was obtained after an initial distribution phase. Evidence of non‐linear kinetics for plasma levels below 0.6 μg ml−1 was also obtained. Other 1,3,8‐trisubstituted xanthines, may also have a lower elimination rate than theophylline.