Effects of Stroke Localization on Cardiac Autonomic Balance and Sudden Death

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Abstract
Background and Purpose —Stroke has been shown to alter autonomic function. The purpose of this study was to show the differential effects of stroke localization on autonomic function parameters assessed by heart rate variability (HRV). Methods —To determine the differential effect of ischemic stroke localization on autonomic cardiac innervation, we evaluated 62 patients with ischemic stroke and 62 age- and sex-matched controls. The localization of the infarct was determined by CT and MRI. Power spectrum analysis of HRV was performed. Myocardial necrosis was ruled out by echocardiography and creatine kinase myocardial isoenzymes measurements. Results —All stroke patients had significantly decreased low frequency, high frequency, and standard deviation of all relative risk intervals values ( P P Conclusion —We conclude that stroke in the region of insula (especially the right) leads to decreased HRV and to increased incidence of sudden death.