The Fragile Histidine Triad Gene: A Molecular Link Between Cigarette Smoking and Cervical Cancer
- 15 August 2005
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 11 (16) , 5756-5763
- https://doi.org/10.1158/1078-0432.ccr-05-0234
Abstract
Purpose: Smoking is an epidemiologic risk factor for cervical cancer. The fragile histidine triad (FHIT) gene is a tumor suppressor gene that is altered in 80% of tobacco-associated lung cancers. We hypothesized that reduced FHIT protein expression, homozygous deletions (HD) or hemizygous deletions (HemiD) and microsatellite alterations (MA) at the FHIT/FRA3B locus occur more commonly in cervical cancers of smokers than nonsmokers.Keywords
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