Treatment of Bowen's disease with topical 5-fluorouracil under occlusion

1 February 1968

journal article
research article
Published by American Medical Association (AMA) in Archives of Dermatology

Vol. 97 (2) , 178-180
https://doi.org/10.1001/archderm.97.2.178

Abstract

Therapy with topically administered 5-fluorouracil under occlusion proved remarkably successful in resolving a large protuberant 8 x 10-cm lesion of Bowen''s disease on the thigh of an 83-year-old man. Within 12 days, the lesion had sloughed and by 1 month the epidermis had returned to normal. Further trials with this agent under occlusion are warranted for the treatment of superficial malignancies.