Relationship Between Physical Activity and Inflammation Among Apparently Healthy Middle-aged and Older US Adults

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Abstract
A NUMBER OF STUDIES have shown that physical activity is associated with a lower risk of coronary heart disease (CHD).1-7 The mechanisms underlying this association are not entirely clear. Recent reports have indicated that markers of inflammation are predictive of increased CHD incidence and mortality,3,8-14 and the development of CHD is increasingly being viewed as an inflammatory process.15 As such, it might be reasonable to hypothesize that if physical activity lowers CHD risk, it may do so in part by preventing or reducing inflammation.