PS-5, a new .BETA.-lactam antibiotic. III. Synergistic effects and inhibitory activity against a .BETA.-lactamase.
- 1 January 1979
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 32 (4) , 280-286
- https://doi.org/10.7164/antibiotics.32.280
Abstract
PS-5 was shown to have synergistic activity in combination with other β-lactam antibiotics and it markedly decreased the minimum inhibitory concentration values of ampicillin or cephaloridine with a β-lactamase-producing Proteus vulgaris strain on agar plates. The synergistic activities were also shown in bactericidal activity in liquid medium. PS-5 was shown to be inhibitory against an extracted β-lactamase of P. vulgaris.This publication has 1 reference indexed in Scilit:
- Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerusAntimicrobial Agents and Chemotherapy, 1977