EFFECT OF SUBSTANCE-P ON CATECHOLAMINE SECRETION FROM RAT ADRENAL-MEDULLA INSITU
- 1 January 1989
- journal article
- research article
- Vol. 48 (10) , 839-842
Abstract
Splanchnic nerve stimulation caused a frequency-dependent increase in catecholamine (CA) secretion with a maximum at 10 Hz from adrenal medulla of WKY rats in situ. Substance P (SP(1-11)) had no effect on the basal output of CA. During nerve stimulation, however, SP(1-11) decreased only the adrenaline (A) secretion by 18% at 10 Hz and by 55% at 20 Hz (p < 0.05), whereas the noradrenaline (NA) secretion remained unchanged. These results provide further evidence that SP(1-11) may modulate frequency-dependently the secretion of CA from adrenal medulla in situ.This publication has 1 reference indexed in Scilit:
- Effects of desipramine, trifluoperazine and other inhibitors of calmodulin on the secretion of catecholamines from the adrenal medulla and postganglionic sympathetic nerves of the salivery glandNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1984