Discovery of the Ceruloplasmin Homologue Hephaestin: New Insight into the Copper/Iron Connection
- 1 January 2000
- journal article
- review article
- Published by Oxford University Press (OUP) in Nutrition Reviews
- Vol. 58 (1) , 22-26
- https://doi.org/10.1111/j.1753-4887.2000.tb01821.x
Abstract
Approximately 75 years ago Hart and colleagues discovered that copper deficiency impaired mammalian iron metabolism. Discovery of hephaestin identifies a critical new component of the copper and iron connection in mammals. Hephaestin appears to be a multicopper oxidase required for efficient export of iron from the intestine.Keywords
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