Synthesis of Immunoglobulin Heavy and Light Chains by the Free Ribosomes of a Mouse Plasma Cell Tumor
- 1 June 1970
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 66 (2) , 425-432
- https://doi.org/10.1073/pnas.66.2.425
Abstract
Free and membrane-bound ribosomes have been isolated from a mouse plasma cell tumor secreting immunoglobulins, and allowed to synthesize proteins under cell-free conditions. Analysis of the products of synthesis by autoradiography of immunoelectrophoresis and peptide maps indicates that both types of ribosomes synthesize heavy and light immunoglobulin chains.Keywords
This publication has 13 references indexed in Scilit:
- CONTROLLED PROTEOLYSIS OF NASCENT POLYPEPTIDES IN RAT LIVER CELL FRACTIONSThe Journal of cell biology, 1970
- Biosynthesis of Serum Proteins and Ferritin by Free and Attached Ribosomes of Rat LiverJournal of Biological Chemistry, 1969
- Preferential Synthesis of Ferritin and Albumin by Different Populations of Liver PolysomesScience, 1969
- Ribosomes in rat liver: An estimate of the percentage of free and membrane-bound ribosomes interacting with messenger RNA in vivoJournal of Molecular Biology, 1967
- Comparison of Guinea Pig γ1- and γ2-Immunoglobulins by Peptide Mapping*Biochemistry, 1967
- Free and Membrane-bound Ribosomes in Rat LiverJournal of Biological Chemistry, 1967
- Isolation and properties of polyribosomes and fragments of the endoplasmic reticulum from rat liverBiochemical Journal, 1967
- Vectorial discharge of peptides released by puromycin from attached ribosomes.Proceedings of the National Academy of Sciences, 1966
- Heritable variation in bence jones protein structure in an inbred strain of miceJournal of Molecular Biology, 1964
- A Cytochemical Study on the Pancreas of the Guinea PigThe Journal of cell biology, 1960