INTRA-AMNIOTIC PROSTAGLANDIN-F2ALPHA AND UREA FOR MIDTRIMESTER-ABORTION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 27  (12) , 1374-1379
Abstract
Intra-amniotic prostaglandin F2.alpha. in doses of 2.5 to 20 mg combined with 80 g of urea was an effective, safe, simple and economical midtrimester abortifacient in 115 patients. The mean abortal time, 15.8 h was significantly less than that in prior series in which intra-amniotic hypertonic saline or urea was administered together with constant i.v. oxytocin infusion. The use of intracervical laminaria tents did not shorten the abortal time. Only 8 patients had not aborted within 30 h; only 2 had not aborted within 36 h; and only 6 received a 2nd intraamniotic injection. Operative removal of the placenta, when necessary, was accomplished under i.v. sedation in a treatment room. The incidence of infection, nausea, vomiting and other complications was low.

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