Allergic and photoallergic dermatitis from diphenhydramine

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Abstract
A 52-yr-old man developed contact and photoallergic dermatitis caused by diphenhydramine hydrochloride; he developed contact dermatitis from paraphenylenediamine. The diphenhydramine photoallergy was elicited by long-wave UV light. The action spectrum differs from that noted in a recent report in which wavelengths shorter than 320 nm were responsible for eliciting diphenhydramine photoallergy. This is the 3rd known case of diphenhydramine photosensitivity reported. The combination of contact and photosensitivity to diphenhydramine was not previously described.

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