The behaviour in presence of phenol or thymol of a strain ofSaccharomyces cerevisiae

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Abstract
Phenol lowers the growth rate of a strain of Saccharomyces cerevisiae without causing any appreciable initial lag in growth. Improvement in the growth rate on repeated subculture (‘training’) is not very marked. In contrast, thymol induces a long initial lag which is rapidly eliminated by training. The adapted yeast strain shows a curve of lag against concentration displaced to considerably higher concentrations. As the yeast becomes adapted to thymol it loses the power of sporulation progressively, and recovers it, again gradually, as the adaptation is lost on continued passage through media without thymol. The development of resistance may be adaptive or mutational, though reasons are given for considering the former more probable.