Striated muscle in the lung

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Abstract
The occurrence of striated muscle in an “extralobar pulmonary sequestration,” a typical “accessory lobe,” has been described for the first time in an infant with the respiratory distress syndrome of the newborn. The few published cases of the presence of striated muscle in the lungs have been reviewed. In most instances they were associated with benign or malignant tumor formation. The simultaneous occurrence of a pulmonary sequestration and striated muscle is explained by postulating the displacement of a fragment from the lung bud early in its development. This view eliminates the necessity of invoking an additional pathological happening in the sequestrated lung in the form of a “metaplastic transformation” of either smooth muscle or embryonic connective tissue into striated muscle. While a heteroplastic transformation may occur in instances of malignant tumor formation, striated muscle in the developmental anomaly described here may well form on an entirely different basis.