Variability of Capillary Plasma Glucose in Healthy Individuals in Repeated 75 g Oral Glucose Tolerance Tests
- 1 November 1988
- journal article
- research article
- Published by SAGE Publications in Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
- Vol. 25 (6) , 634-637
- https://doi.org/10.1177/000456328802500606
Abstract
A series of ten 75g oral glucose tolerance tests was carried out on each of 14 apparently healthy subjects. The analytical, intra-individual and inter-individual components of variation were calculated by nested ANOVA following duplicate analyses of capillary plasma glucose under optimal conditions. The analyses met the objectively set analytical goal of CV ≤2·2%. There was considerable intra-individual variation, but no subject was ever classified as diabetic or having impaired glucose tolerance. Recent criteria for interpretation of results must be used since conventional population-based reference values are not adequate. Serial results from an individual must differ by more than 0·7 mmol/L for fasting specimens and at least 1·6 mmol/L for other specimens for a statistically significant ( P ≤ 0·05) change to have occurred.This publication has 9 references indexed in Scilit:
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