Diabetic State with Lipaemia and Hydropic Changes in the Pancreas Produced in Rabbits by Cortisone.

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Abstract
During the course of an expt. in which rabbits were placed in a cold room at 8-30[degree] F and treated with intraven. horse serum, some of the animals who were also receiving 20 mg. of Cortisone per day developed a marked glycosuria and hyper-glycaemia. This was accompanied by an increasing visible lipaemia due to elevation of fatty acids of neutral fat, lipid P as well as free and total cholesterol. Two of the animals died, one after 12 days of Cortisone treatment and the other after 22 days of treatment. In the latter animal, marked hydropic change (glycogen vacuolation) of the ductular cells and beta islet cells of the pancreas was observed. The antemortem and postmortem findings are similar to those seen in alloxan diabetes in rabbits. The possibile significance of the lipaemia in exptl. atherosclerosis, and of all the findings in the study of diabetes and in the treatment of human disease, is discussed briefly.

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