EFFECT OF DIFFERENT DIETS ON THE RATIO OF PLASMA-LIPIDS VITAMIN-A AND VITAMIN-E IN FEMALE SPRAGUE-DAWLEY RATS WITH MNU-INDUCED MAMMARY CARCINOMAS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 55  (6) , 443-450
Abstract
An inverse relationship between vitamin A uptake and cancer as well as serum cholesterol concentration and cancer has been shown. An inverse relationship between serum cholesterol and retinol has been reported. In a study, in which female Sprague-Dawley rats with MNU-induced mammary tumors were fed diets containing different amounts of fat and vitamins A and E, the effect of these diets on the inverse association between the cancer risk and both plasma lipids and vitamin A, E was investigated. According to the data obtained there is not only a relationship between plasma cholesterol and vitamin A, but also a similar relationship between cholesterol and vitamin E. The relationship between triglycerides and the two vitamins was also parallel to that of the cholesterol-vitamin A relationship. The interactions between cancer, plasma lipids and vitamin A, E could be modified by certain diets. However, further studies will be needed to elucidate these interactions.