Antisera with la Specificity Selected by Lymphocytes from Patients with Chronic Lymphocytic Leukemia
- 1 April 1978
- journal article
- research article
- Published by Wiley in Vox Sanguinis
- Vol. 34 (4) , 200-207
- https://doi.org/10.1111/j.1423-0410.1978.tb02468.x
Abstract
Cells from patients with chronic lymphocytic leukemia (CLL) were used to screen the sera of pregnant women for antibodies specific for B [bone marrow-derived] lymphocytes. The sera were divided into groups showing Ia [immune response-associated] specificity: group I (UK 3) had a positive association with HLA-B8 and DW 3, and group II (UK 2) with HLA-B7 and DW2. Groups III, IV and X were independent of each other and of HLA-A, B and C locus antigens. Certain sera with B cell activity showed specific blocking activity in the mixed lymphocyte reaction (MLR), and this activity was dependent on the Ia specificities and DW specificities of cells used in the MLR. Some sera specifically blocked the responding cells, others the stimulating cells.This publication has 7 references indexed in Scilit:
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