Association Between Apolipoprotein Eϵ4 and the Rate of Cognitive Decline in Community-Dwelling Elderly Individuals With and Without Dementia

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Abstract
ALTHOUGH the apolipoprotein E ϵ4 allele (apoE ϵ4) has been repeatedly demonstrated to be a risk factor for sporadic and familial Alzheimer disease (AD),1-3 the mechanisms by which the allele may alter the risk for dementia are not well understood. One indication of how apoE ϵ4 may be involved in the disease process is the extent to which the allele is associated with or prognostic for disease progression in the subclinical and clinical stages of AD.