Biological Activities of Lipid A Complexed with Bovine‐Serum Albumin
Open Access
- 1 December 1972
- journal article
- Published by Wiley in European Journal of Biochemistry
- Vol. 31 (2) , 230-233
- https://doi.org/10.1111/j.1432-1033.1972.tb02524.x
Abstract
Lipid A preparations from the lipopolysaccharides of four Salmonella minnesota R mutants and one Escherichia coli 0100 R mutant were assayed as soluble complexes with bovine serum albumin for lethality in mice, pyrogenicity in rabbits and complement inactivation. Although generally less active than endotoxic lipopolysaccharides, these lipid · albumin complexes nevertheless exhibited strong biological activity. These results indicate that lipid A contains the endotoxic principle of bacterial lipopolysaccharides.Keywords
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