Synthesis of (±)-15-thia-15-deoxy-PGE1 methyl ester
- 1 January 1994
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 72 (1) , 1-5
- https://doi.org/10.1139/v94-001
Abstract
The 15-thia-15-deoxy analogue of prostaglandin E1 methyl ester has been prepared by the zirconocene chloride mediated conjugate addition of an n-pentyl ethynyl sulfide derived anion to an appropriately substituted cyclopentenone. Similar methodology has also been used to prepare other 3-(3′-thia-1′-octenyl)-cyclopentanones.Keywords
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