The inhibition of carbohydrate metabolism in ascites-tumour cells by ethyleneimines

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Abstract
2:4:6-Triethyleneimino-l:3:5-triazine (TEM) inhibits respiration and glycolysis in mouse ascites-tumor cells and in a number of rat tissues. Isolated preparations of hexokinase and triose phosphate dehydrogenase are only slightly affected by TEM, but phosphofructokinase is readily inhibited. Fructose diphosphate and triose phosphate accumulate, while the DPN concentration,falls sharply, concurrently with the onset of inhibition of anaerobic glycolysis in ascites-tumor cells by TEM. Nicotinamide and a number of DPNase inhibitors protect against this inhibiting effect of TEM. The inhibition is considered to be due to a rapid breakdown of DPN induced by TEM.