Differential Antibiotic Susceptibilities of Starved Mycobacterium tuberculosis Isolates
Open Access
- 1 November 2005
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (11) , 4778-4780
- https://doi.org/10.1128/aac.49.11.4778-4780.2005
Abstract
We compared the efficacies of 17 agents against rapidly growing and starved Mycobacterium tuberculosis H37Rv. Few compounds have significant activity at attainable concentrations. However, two phenothiazine compounds at similar concentrations were bactericidal for starved and growing cells. These drugs appear to target a process important in both replicating and nonreplicating bacteria.Keywords
This publication has 16 references indexed in Scilit:
- Capreomycin is active against non-replicating M. tuberculosisAnnals of Clinical Microbiology and Antimicrobials, 2005
- The Transcriptional Responses of Mycobacterium tuberculosis to Inhibitors of MetabolismJournal of Biological Chemistry, 2004
- M. tuberculosis persistence, latency, and drug toleranceTuberculosis, 2003
- Clinical Concentrations of Thioridazine Kill Intracellular Multidrug-Resistant Mycobacterium tuberculosisAntimicrobial Agents and Chemotherapy, 2003
- Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profilingMolecular Microbiology, 2002
- Drug Tolerance in Mycobacterium tuberculosisAntimicrobial Agents and Chemotherapy, 1999
- Starvation- and Stationary-phase-induced resistance to the antimicrobial peptide polymyxin B in Salmonella typhimurium is RpoS (sigma(S)) independent and occurs through both phoP-dependent and -independent pathwaysJournal of Bacteriology, 1996
- Bactericidal activity of antimicrobial agents against slowly growing Helicobacter pyloriAntimicrobial Agents and Chemotherapy, 1992
- Bactericidal effects of antibiotics on slowly growing and nongrowing bacteriaAntimicrobial Agents and Chemotherapy, 1991
- Mechanism of phenotypic tolerance of nongrowing pneumococci to beta-lactam antibiotics.1990