Thymus-Dependent Sensitizing Processes Involved in the Induction of CNS Disease in Mice by Parainfluenza Type 1 Virus

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Abstract
Parainfluenza type 1 virus injected intracerebrally into adult mice induced a mononuclear cell infiltration in the subarchnoidal and perivascular spaces, exudation of inflammatory cells into parenchymal tissue and preferential chronic degeneration of white matter (1, 2). No correlation was found between the severity of the central nervous system (CNS)2 lesions and the levels of circulating hemagglutination inhibition antibody (2). Inactivation of the virus by ultraviolet light (UV) did not affect the ability of the virus to produce the CNS lesions in these mice (3). As part of an inquiry into the mechanisms involved in the production of CNS lesions, the present study reports the response of athymic nude mice and sensitization through prior CNS exposure to virus antigen in immunocompetent mice. Materials and Methods. Inocula. The 6/94 strain of parainfluenza type 1 virus, originally isolated from cell cultures of brain tissue from two multiple sclerosis patients (4), was propagated in embryonated hen's eggs.

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