Inhibition of Antibacterial Activity of Cycloserine by Alpha-Alanine.

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Abstract
The amino acid, [alpha]-alanine, inhibits the antibacterial activity of cycloserine, on staphylococci. The concentration of cycloserine required for inhibition of a strain of Staphylococcus was 500 times greater in the presence of [alpha]-alanine, 50 [mu]g/ml, than in its absence. Evidence is presented justifying the conclusion that the inhibition is of a competitive nature. Similar interference in the action of cycloserine [alpha]-alanine on other organisms such as Escherichia coli, Bacillus cereus, and Shigella flexneri was not observed. No evidence was obtained that [alpha]-alanine interfered with the action of various other antibiotic agents studied.

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