The relationship between collagen and C1q biosynthesis in cultured human fibroblasts

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Abstract
The relationship between collagen and C1q [complement component 1q] biosynthesis was investigated in cultured human fibroblasts. This was done by measuring the effects of variation in cell density, inhibition of prolyl hydroxylase and complexing of C1q on synthesis and/or secretion of both proteins. Synthesis and secretion of both proteins were not co-ordinate, and regulation of expression of both proteins is probably not linked. Complexing of C1q did result in marked stimulation in collagen synthesis, suggesting that the fibrosis which follows inflammation may result from binding of C1q to the immune complexes formed in the inflammatory process.