Long-term Suppression of Luteinizing Hormone, Follicle-stimulating Hormone and Testosterone by Daily Administration of Leuprolide

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Abstract
The chronic effect of long-term injections of leuprolide on the hypothalamic, pituitary and gonadal axes have been studied in men with advanced prostatic cancer. The possibility of transient acute changes in luteinizing hormone, follicle-stimulating hormone and testosterone after each daily injection was studied in 31 patients treated for more than 1 year. No evidence of escape from daily 1.0 mg doses was noted. No pituitary responsiveness was observed at any time point examined. Thus, daily administration of 1.0 mg leuprolide acetate subcutaneously produces durable, complete suppression of gonadotropins and testosterone for prolonged periods.