Altered Cardiovascular Responses to Glutamate and Acetylcholine Microinjected into the Nucleus Tractus Solitarii of the SHR
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in Clinical and Experimental Hypertension. Part A: Theory and Practice
- Vol. 13 (5) , 661-668
- https://doi.org/10.3109/10641969109042069
Abstract
L-glutamate (GLU) or acetylcholine (ACh) injected into the nucleus tractus solitarii (NTS) of rat elicits a decrease in arterial pressure (AP) and heart rate (HR) similar to that seen with activation of the baroreflex. Both compounds may play a role in the mediation of the baroreflex at the level of NTS. The baroreflex may be disturbed in the spontaneously hypertensive rat (SHR). Thus we sought to determine if the dose-related responses to microin-jection (50 nl) of the two putative transmitters into NTS may be altered inKeywords
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