Human monocytes can produce tissue-type plasminogen activator.
Open Access
- 1 April 1989
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 169 (4) , 1509-1514
- https://doi.org/10.1084/jem.169.4.1509
Abstract
Evidence has previously been presented that monocytes and macrophages produce urokinase-type plasminogen activator. We have shown for the first time that human monocytes, when stimulated appropriately in vitro, can produce tissue type-plasminogen activator (t-PA) of 70 kD. Detection of t-PA mRNA was consistent with the biochemical and immunological characterization of t-PA produced by human monocytes.This publication has 16 references indexed in Scilit:
- Synergistic activation of human monocytes by granulocyte-macrophage colony-stimulating factor and IFN-gamma. Increased TNF-alpha but not IL-1 activity.The Journal of Immunology, 1988
- INCREASED RELEASE OF PLASMINOGEN-ACTIVATOR INHIBITOR TYPE-2 ACCOMPANIES THE HUMAN MONONUCLEAR CELL TISSUE FACTOR RESPONSE TO LIPOPOLYSACCHARIDE1988
- BLOOD-CELLS PARTICIPATE IN THE FIBRINOLYTIC RESPONSE TO TISSUE-TYPE PLASMINOGEN-ACTIVATOR1987
- The Pathogenesis of Atherosclerosis — An UpdateNew England Journal of Medicine, 1986
- Plasminogen activation and regulation of pericellular proteolysisBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1985
- Isolation and characterization of the human tissue-type plasminogen activator structural gene including its 5' flanking region.Journal of Biological Chemistry, 1985
- Urokinase‐type plasminogen activator and its inhibitor secreted by cultured human monocyte‐macrophagesJournal of Cellular Physiology, 1984
- Concomitant secretion of prourokinase and of a plasminogen activator-specific inhibitor by cultured human monocytes-macrophages.The Journal of Experimental Medicine, 1984
- Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. Characterization of a plasminogen activator and its role in matrix degradation.Journal of Clinical Investigation, 1984
- Novel properties of human monocyte plasminogen activatorEuropean Journal of Biochemistry, 1984