Interaction between Human IgD and Ricinus Agglutinin

Abstract
The results show that monoclonal IgD reacts specifically with ricinus agglutinin (molecular weight 120.000) (RcA1). The reaction between IgD and RcA1 was inhibited by galactose and lactose but not by glucose, indicating that the interaction is mediated by galactose containing carbohydrate units located in or near the σ‐hinge region. Affinity chromatography on RcA1‐Sepharose 4B was successfully used lo isolate monoclonal IgD from the IgD myeloma plasma.