Macrophage migration inhibitory factor in rheumatoid pericarditis

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Abstract
The pericardial effusion in a case of rheumatoid pericarditis was studied to determine whether immune complexes and mediators of cellular immunity, represented by migration inhibitory factor (MIF), were present. MIF‐like activity was detected in the pericardial fluid, but only traces of immune complexes were revealed by ultracentrifugation. The MIF‐like activity was partially characterized by column fractionation and sugar inhibition tests. The role of lymphokines in the pathogenesis of this case of rheumatoid pericarditis is strongly suggested.