1‐Isopropylamino‐3‐(4‐indanoxy)‐2‐propanol HCl: a potent β‐adrenoceptor antagonist

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Abstract
1 . The β-adrenoceptor blocking activity of 1-Isopropylamino-3-(4-indanoxy)-2-propanol HC1 (USVC 6524) was determined in the anaesthetized dog, the isolated rat uterus and the isolated guinea-pig tracheal strip. 2 . USVC 6524 inhibited the positive inotropic, positive chronotropic and vasodilator responses to isoprenaline in the dog in a dose of 10 μg/kg and higher. On the basis of comparative pA2 values, USVC 6524 is approximately 10 times more potent as a β-adrenoceptor antagonist than propranolol. 3 . Cardiac depressant effects produced by USVC 6524 were relatively mild and occurred only after the onset of a strong β-adrenoceptor blockade. 4 . USVC 6524 also blocked β-adrenoceptors in the isolated rat uterus and guinea-pig tracheal spiral strip.

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