Identification of an inhibitor of microtubule assembly present in juvenile brain which displays a novel mechanism of action involving suppression of self-nucleation
- 1 November 1991
- journal article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 30 (44) , 10813-10817
- https://doi.org/10.1021/bi00108a030
Abstract
An inhibitor of microtubule assembly has been identified and partially purified from microtubule-depleted brain extracts from day-old chicks and 4-month-old calf. This inhibitor suppresses the self-nucleation of microtubules in vitro with minimal effect upon the final extent of assembly. It may have a developmental role in vivo as it is not detected in adult brain from either cattle or rabbit.Keywords
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