CELL-MEMBRANE IONIC PERMEABILITY AND MITOCHONDRIA CHANGES DURING 4-DIMETHYL-AMINOAZOBENZENE CARCINOGENESIS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 46  (5) , 389-392
Abstract
In rats fed 4-dimethylaminoazobenzene there is an increase of Ca and Na in liver accompanied by a decrease of Mg and K. This influx of extracellular cations is explained as the result of cell membrane modifications due to carcinogen action. Mitochondria showed the highest Ca content at the time of maximum tumor incidence. The interrelationship between cell membrane permeability changes and mitochondrial damage through Ca overloading as a cancer triggering event is discussed.

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