Cholesterol metabolism in the laying fowl

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Abstract
Various aspects of cholesterol metabolism in the laying hen were studied by the use of radioactive tracers. The biological half-life of plasma cholesterol-14C was 36 hr. When the cholesterol-14C was given orally there was a rapid buildup of the 14C-labeled cholesterol in the liver, plasma, and intestine and then a rapid turnover into 2 excretory pathways, egg and fecrs. It was shown that the plasma and egg "isotopic steady-state" conditions were obtained by the time the hens were fed the steady-state diet for 21 days. This steady-state data indicate that if ovarian synthesis does occur in vivo, it accounts for a very small amount of the total cholesterol deposited in the egg. Data were presented to indicate that plasma cholesterol is incorporated into the brain of the adult fowl to a small extent and some cholesterol may be synthesized in the brain of the adult fowl.

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