AP-1 as a regulator of cell life and death
Top Cited Papers
- 1 May 2002
- journal article
- review article
- Published by Springer Nature in Nature Cell Biology
- Vol. 4 (5) , E131-E136
- https://doi.org/10.1038/ncb0502-e131
Abstract
The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation, transformation and death. Using mice and cells lacking AP-1 components, the target-genes and molecular mechanisms mediating these processes were recently identified. Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators. Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate relationships between the different Jun proteins, their activities and the mechanisms that mediate them will be discussed.Keywords
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