Electrical Stimulation of Metabolism of Homogenates and Particulates

Publisher Website
Google Scholar
Abstract
Homogenates of brain, but not liver or kidney, and mitochondrial suspensions from brain or liver increase their O2 consumption twofold or more, with an appropriate increased loss of substrate, when "stimulated" by current pulses. Phosphorylation is decreased (due to inhibition of esterification rather than acceleration of splitting) in brain homogenate or mitochondria, but not in liver, by these currents. Currents do not alter the action of soluble enzyme involved in glycolysis, dehydrogenation, dephosphorylation etc. The results are discussed briefly in relation to structural organization and to physiological function.