Production of Staphylococcus Antitoxin in Horses

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Abstract
It has been shown by one of us (1, 2) that most strains of Staphylococcus aureus from pathogenic sources produce a poison which in 0.1 cc. amounts causes marked necrosis when injected into the skin of rabbits. At the time of writing these papers we were not aware that von Lingelsheim (3) as early as 1900 described experiments in which he inoculated subcutaneously 8 to 10 cc. of sterile filtrates of broth cultures of Staphylococcus aureus and obtained marked inflammatory changes and sometimes necrosis. More recently, Neisser and Wechsberg (4) confirmed these findings with smaller injections (0.2 to 0.3 cc.) of toxic filtrates. These observers found as we did that this necrotizing poison was destroyed when heated to 58° for one hour. On further analysis, we showed this poison to be an exotoxin as the serum of rabbits immunized thereto neutralized it in multiple quantities.

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