DNA Helicases Required for Homologous Recombination and Repair of Damaged Replication Forks
- 1 December 2006
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genetics
- Vol. 40 (1) , 279-306
- https://doi.org/10.1146/annurev.genet.40.110405.090636
Abstract
DNA helicases are found in all kingdoms of life and function in all DNA metabolic processes where the two strands of duplex DNA require to be separated. Here, we review recent developments in our understanding of the roles that helicases play in the intimately linked processes of replication fork repair and homologous recombination, and highlight how the cell has evolved many distinct, and sometimes antagonistic, uses for these enzymes.Keywords
This publication has 99 references indexed in Scilit:
- Escherichia coli RecQ helicase: A player in thymineless deathMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005
- A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group MNature Genetics, 2005
- The DNA helicase BRIP1 is defective in Fanconi anemia complementation group JNature Genetics, 2005
- The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repairNature Genetics, 2005
- DNA helicase Srs2 disrupts the Rad51 presynaptic filamentNature, 2003
- Direct Rescue of Stalled DNA Replication Forks via the Combined Action of PriA and RecG Helicase ActivitiesMolecular Cell, 2002
- A General Model for Nucleic Acid Helicases and Their “Coupling” within Macromolecular MachinesCell, 2001
- The Translocating RecBCD Enzyme Stimulates Recombination by Directing RecA Protein onto ssDNA in a χ-Regulated MannerCell, 1997
- Crystal structure of a DExx box DNA helicaseNature, 1996
- The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formationCell, 1994