Direct 1H NMR determination of the enantiomeric excess of carnitine
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 113 (7) , 1143-1144
- https://doi.org/10.1039/an9881301143
Abstract
The enantiomeric purity of carnitine may be determined without any derivatisation of the molecule. Preparations of aqueous mixtures containing stereochemically pure L-malic acid, carnitine and europium trichloride lead to the formation of a complex in which the trimethylammonium groups of D- and L-carnitine are diastereotopic. The resolution is observed only when strict experimental conditions are maintained.Keywords
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