A Facile Synthesis of (−)-(4R,5R)-4,5-(Isopropylidenedioxy)-2-cyclopentenone, a Useful Precursor tod-Like Carbanucleosides
- 5 January 2003
- journal article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 33 (9) , 1477-1481
- https://doi.org/10.1081/scc-120018765
Abstract
A facile synthesis of (−)-(4R,5R)-4,5-(isopropylidenedioxy)-2-cyclopentenone ((−)-2), as a precursor to d-like carbanucleosides, is described in 5 steps from (1S,4R)-4-acetoxycyclopent-2-en-1-ol (3). Compound 3 has also been described in the literature as amenable to the formation of (+)-2, thus making both the d-like and l-like carbanucleosides available from the same readily available 3.Keywords
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