Methotrexate and trimethoprim-sulphamethoxazole-a potentially hazardous combination
- 1 September 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical and Experimental Dermatology
- Vol. 15 (5) , 358-360
- https://doi.org/10.1111/j.1365-2230.1990.tb02113.x
Abstract
A 74-year-old woman had been treated with methotrexate over 2 years for rheumatoid arthritis. She was admitted to the hospital because of non-healing leg ulcers. After being treated with trimethoprim-sulphamethoxazole for a urinary-tract infection, she developed severe pancytopenia, followed by pneumonia and septic shock. The patient died shortly after. Concomitant treatment with methotrexate and sulphonamides should be strongly discouraged.This publication has 10 references indexed in Scilit:
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