Changes in the fine structure of the dental pulp in human caries pulpitis

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Abstract
An investigation into the nature of the inflammatory infiltrate of early caries pulpitis in humans indicates that the basis response is a mononuclear one in which plasma cells predominate. From their morphological appearance it could be stated that the plasma cells present were engaged in the formation of antibody. It was suggested that the stimulus for this antibody production could arise from substances in the carious lesion or from locally sensitized dental pulp. Although several methods of antibody release from plasma cells were discussed, the only one noted in the study was that occurring as a result of the apparent fusion of distended cisternae of rough endoplasmic reticulum with the plasma membrane.