Induction of haem synthesis in Hep G2 human hepatoma cells by dimethyl sulphoxide. A transcriptionally activated event
- 14 July 1986
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 237 (2) , 597-600
- https://doi.org/10.1042/bj2370597
Abstract
Exposure of cultured human hepatoma cells (Hep G2) to medium containing 2% (v/v) dimethyl sulphoxide resulted in an approximate doubling in the activity of delta-aminolaevulinate dehydratase, an increase in the haem content and a decreased growth rate; induced enzyme activity was decrease by 50% after treatment with alpha-amanitin. The findings are strikingly similar to those seen in murine Friend-virus-transformed erythroleukaemia cells.This publication has 31 references indexed in Scilit:
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