Diurnal Variation in Cerebrospinal Fluid Prolactin Concentration of the Rhesus Monkey

Abstract
PRL immunoreactivity in the cerebrospinal fluid (CSF) of the rhesus monkey was found to undergo a diurnal variation. Hourly samples of CSF from four adult male rhesus monkeys showed a mean peak PRL immunoreactivity of 6.30 ± 2.53 ng±ml at 0200 h and a mean minimum concentration at 1500 h of 3.15 ± .68 ng/ml. To our knowledge, this is the first report of a significant diurnal variation in the concentration of an anterior pituitary peptide hormone in CSF. (J Clin Endocrlnol Metab52: 857, 1981)

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