THE PARTITION OF PLASMA CALCIUM AND INORGANIC PHOSPHORUS IN ESTROGENTREATED NORMAL AND PARATHYROIDECTOMIZED PIGEONS

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Abstract
Estrogens increase the plasma Ca and inorganic P of normal, parathyroidectomized, and hypophysectomized pigeons. The effect is primarily on the non-ultrafiltrable fraction of both of these components. The increases varied from 2-10 fold and were approx, equal in the 3 types of birds. No significant change was observed in the ultrafiltrable fraction of either Ca or P. In estrogen-treated pigeons there is a direct relationship between the increase in the non-ultrafiltrable fractions of Ca and inorganic P. A correlation coefficient of .960 [plus or minus] .014 was obtained. One-third of the non-ultrafiltrable Ca in such pigeons can be accounted for as colloidal Ca phosphate. In 3 tests on normal pigeons the androgen, androstenedione, did not increase either ultrafiltrable or non-ultrafiltrable Ca or P. Parathyroidectomy in the pigeon is usually followed by a decrease in ultrafiltrable Ca and an increase in ultrafiltrable P. Prolonged adm. of A1(OH)3 (gel) reversed both of these changes.