HEMODYNAMIC REACTIONS AFTER INTRAVENOUS-INJECTION OF LORCAINIDE HYDROCHLORIDE IN ACUTE MYOCARDIAL-INFARCTION
- 1 January 1981
- journal article
- research article
- Vol. 12 (5) , 237-242
Abstract
Lorcainide hydrochloride given at the dose of 150 mg i.v. was well tolerated by patients in the acute stage of a myocardial infarction; the subjective signs were benign and never prevented injection completion. The hemodynamic changes reflect some depressive effects on the myocardial function. Most of the observed changes are transient, and when significant from the statistical point of view, they remain very mild; the cardiac output decreased from 3.4 to 3.2 1/min per m2, the stroke index from 46 to 41 ml/m2, the pulmonary wedge pressure increases from 6.6 to 8.4 mm Hg (mean values). Lorcainide hydrochloride may be used as an antiarrhythmic drug in acute myocardial infarction.This publication has 4 references indexed in Scilit:
- Initial clinical experience of lorcainide (Ro 13-1042), a new antiarrhythmic agentEuropean Journal of Clinical Pharmacology, 1978
- ANTIARRHYTHMIC, ELECTROPHYSIOLOGIC AND HEMODYNAMIC EFFECTS OF LORCAINIDE1978
- CLINICAL EXPERIENCE WITH LORCAINIDE (R 15 889), A NEW ANTI-ARRHYTHMIC DRUG1977
- Cardiac Output Monitoring During the Acute Phase of Myocardial Infarction: Accuracy and Precision of the Thermodilution MethodCardiology, 1977